In addition to using APBS through other programs, there are two ways to invoke APBS from the command line. The traditional approach uses the primary APBS binary to run APBS on local resources. However, in recent versions of APBS, we have added the ability to run APBS through a secondary Python-based program which can be invoked locally but uses Opal web services to run APBS on remote resources (with no expense to the user).